Cardiac maladaptation in obese pregnancy at term

Buddeberg, B.S., Sharma, R., O'Driscoll, J., Kaelin Agten, A., Khalil, A. and Thilaganathan, B. (2018) Cardiac maladaptation in obese pregnancy at term. Ultrasound in Obstetrics and Gynecology. ISSN 0960-7692.

[img] PDF
17751_Cardiac Maladaptation in Obese Pregnancy Manuscript.pdf - Accepted Version
Restricted to Repository staff only until 31 October 2019.

Download (408kB)


Objectives: Obesity is an increasing problem worldwide with well-recognized detrimental effects on cardiovascular health. However, very little is known about the effect of obesity on cardiovascular adaptation to pregnancy, as existing studies are small and show conflicting results. The aim of the present study is to compare biventricular cardiac function at term in obese pregnant women and pregnant women of normal body weight utilizing conventional echocardiography indices and speckle tracking assessment.

Methods: For this prospective case control study, 40 obese, but otherwise healthy, pregnant women with a body mass index (BMI) ≥35kg/m2 and 40 healthy pregnant women with a BMI ≤30kg/m2 underwent full echocardiography at term.

Results: Obese pregnant women had significantly higher systolic blood pressure (117 vs. 109mmHg, p=0.002), cardiac output (6.73 vs. 4.89L/min, p<0.001), left ventricular mass index (74 vs. 64g/m2, p<0.001) and relative wall thickness (0.43 vs. 0.37, p<0.001). Diastolic dysfunction was present in 12.5% (n=5) of controls and 41% (n=16) of obese women (p=0.004). Left ventricular global longitudinal strain (-15.59 vs. -17.61%, p<0.001), left ventricular endocardial (-17.30 vs. -19.84±%, p<0.001) and epicardial (-13.10 vs. -15.73%, p<0.001) global longitudinal strain as well as left ventricular early diastolic strain rate (1.05 vs. 1.24s-1, p=0.006) were all significantly reduced in the obese group. No differences were observed in left ventricular twist and torsion.

Conclusion: These findings are likely to represent a maladaptive response of the heart to volume overload in pregnancy. The impact of theses changes on pregnancy outcome and long-term maternal outcome is unclear.

Item Type: Article
Uncontrolled Keywords: Cardiac dysfunction; diastolic dysfunction; echocardiography; obesity; pregnancy; speckle tracking
Subjects: R Medicine
R Medicine > RG Gynecology and obstetrics
Divisions: Faculty of Social and Applied Sciences > School of Human and Life Sciences
Depositing User: Dr Jamie O'Driscoll
Date Deposited: 01 Nov 2018 09:40
Last Modified: 07 Feb 2019 15:45

Actions (login required)

Update Item (CReaTE staff only) Update Item (CReaTE staff only)


Downloads per month over past year

View more statistics


Connect with us

Last edited: 29/06/2016 12:23:00