Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans

Wang, Y. A., Kammenga, J. and Harvey, S.C. (2017) Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans. Human Genomics, 11 (1). ISSN 1479-7364.

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Background: Neurodegenerative diseases (NGDs) such as Alzheimer’s and Parkinson’s are debilitating and largely untreatable conditions strongly linked to age. The clinical, neuropathological, and genetic components of NGDs indicate that neurodegeneration is a complex trait determined by multiple genes and by the environment.

Main body: The symptoms of NGDs differ among individuals due to their genetic background, and this variation affects the onset and progression of NGD and NGD-like states. Such genetic variation affects the molecular and cellular processes underlying NGDs, leading to differential clinical phenotypes. So far, we have a limited understanding of the mechanisms of individual background variation. Here, we consider how variation between genetic backgrounds affects the mechanisms of aging and proteostasis in NGD phenotypes. We discuss how the nematode Caenorhabditis elegans can be used to identify the role of variation between genetic backgrounds.Additionally, we review advance s in C. elegans methods that can facilitate the identification of NGD regulators and/or networks.

Conclusion: Genetic variation both in disease genes and in regulatory factors that modulate onset and progression of NGDs are incompletely understood. The nematode C. elegans represents a valuable system in which to address such questions.

Item Type: Article
Additional Information: Open Access journal
Subjects: Q Science
Q Science > QP Physiology
Divisions: Faculty of Social and Applied Sciences > School of Human and Life Sciences
Related URLs:
Depositing User: Dr Simon Harvey
Date Deposited: 30 May 2017 12:36
Last Modified: 21 Aug 2018 09:38

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Last edited: 29/06/2016 12:23:00