Population genetic structure of Taenia solium from Madagascar and Mexico: implications for clinical profile diversity and immunological technology

Vega, R., Piñero, D., Ramanankandrasana, B., Dumas, M., Bouteille, B., Fleury, A., Sciutto, E., Larralde, C. and Fragoso, G. (2003) Population genetic structure of Taenia solium from Madagascar and Mexico: implications for clinical profile diversity and immunological technology. International Journal for Parasitology, 33 (13). pp. 1479-1485. ISSN 00207519.

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Abstract

Taenia solium is a cestode parasitic of humans and pigs that strongly impacts on public health in developing countries. Its larvae (cysticercus) lodge in the brain, causing neurocysticercosis, and in other tissues, like skeletal muscle and subcutaneous space, causing extraneuronal cysticercosis. Prevalences of these two clinical manifestations vary greatly among continents. Also, neurocysticercosis may be clinically heterogeneous, ranging from asymptomatic forms to severely incapacitating and even fatal presentation. Further, vaccine design and diagnosis technology have met with difficulties in sensitivity, specificity and reproducibility. Parasite diversity underlying clinical heterogeneity and technological difficulties is little explored. Here, T. solium genetic population structure and diversity was studied by way of random amplified polymorphic DNA in individual cysticerci collected from pigs in Madagascar and two regions in Mexico. The amplification profiles of T. solium were also compared with those of the murine cysticercus Taenia crassiceps (ORF strain). We show significant genetic differentiation between Madagascar and Mexico and between regions in Mexico, but less so between cysticerci from different localities in Mexico and none between cysticerci from different tissues from the same pig. We also found restricted genetic variability within populations and gene flow was estimated to be low between populations. Thus, genetic differentiation of T. solium suggests that different evolutionary paths have been taken and provides support for its involvement in the differential tissue distribution of cysticerci and varying degrees of severity of the disease. It may also explain difficulties in the development of vaccines and tools for immunodiagnosis.

Item Type: Article
Subjects: Q Science
Q Science > Q Science (General)
Q Science > Q Science (General) > Q0002 General
Q Science > QH Natural history
Q Science > QH Natural history > QH0001 General including nature conservation, geographical distribution
Q Science > QL Zoology
Q Science > QL Zoology > QL0001 General
Q Science > QL Zoology > QL0360 Invertebrates
R Medicine
R Medicine > RB Pathology
R Medicine > RB Pathology > RB0127 Manifestations of disease
Divisions: Faculty of Social and Applied Sciences > School of Human and Life Sciences
Depositing User: Dr Rodrigo Vega
Date Deposited: 27 Apr 2017 14:04
Last Modified: 27 Apr 2017 14:04
URI: https://create.canterbury.ac.uk/id/eprint/15801

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Last edited: 29/06/2016 12:23:00