Autophagy dysfunction and its link to Alzheimer's disease and type II diabetes mellitus.

Wilson, C., Magnaudeix, A., Yardin, C. and Terro, F. (2014) Autophagy dysfunction and its link to Alzheimer's disease and type II diabetes mellitus. CNS Neurol Disord Drug Targets, 13 (2). pp. 226-246. ISSN 1871-5273.

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Abstract

Epidemiological data testifies the increasing incidence of Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM). Some associations were made between occidental lifestyle and development of these pathologies, moreover AD and T2DM are linked since each pathology is a causative risk factor for the other. Interestingly, autophagy, a catabolic pathway whose efficiency declines with age is importantly impaired in the affected tissues. Autophagy regulation is dependent of cell metabolic status and consequently on the 5'AMP-activated protein kinase (AMPK) and mammalian target of rapamycin signaling pathways. These pathways are altered with aging and molecular, pharmacological and physiological interventions increase lifespan in various organismal models and favours healthy aging diminishing the occurrence of age-related diseases such as diabetes, cancer, cardiovascular and neurodegenerative pathologies. Decreasing calorie intake has been known for a long time to have a beneficial effect on longevity and health. Some drug agonists of AMPK are known to mimic these effects such as metformin or resveratrol, a polyphenol extracted from plants and present in red wine, a component of the French paradox related diet. In this review, we present the epidemiological and pathogenesis links existing between AD and T2DM with an insight into the perturbations of the autophagic process highlighting the crucial role of the AMPK in development of age and metabolic related diseases. Hence, in a last part we will discuss the possible interventions susceptible to combat both T2DM and AD.

Item Type: Article
Subjects: R Medicine > RC Internal medicine > RC0435 Psychiatry > RC0512 Psychopathology. Mental disorders > RC0521 Dementia
R Medicine > RC Internal medicine > RC0581 Specialties of internal medicine
R Medicine > RC Internal medicine > RC0581 Specialties of internal medicine > RC0648 Diseases of the endocrine glands. Clinical endocrinology > RC0660 Diabetes
Divisions: Faculty of Social and Applied Sciences > School of Human and Life Sciences
Depositing User: Cornelia Wilson
Date Deposited: 12 Jul 2016 15:32
Last Modified: 12 Jul 2016 15:32
URI: https://create.canterbury.ac.uk/id/eprint/14711

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Last edited: 29/06/2016 12:23:00