Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors.

Wilson, C., Naves, T., Vincent, F., Melloni, B., Bonnaud, F., Lalloue, F. and Jauberteau, M. O. (2014) Sortilin mediates the release and transfer of exosomes in concert with two tyrosine kinase receptors. Journal of Cell Science (JCS), 127 (18). pp. 3983-3997. ISSN 0021-9533.

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Abstract

The transfer of exosomes containing both genetic and protein materials is necessary for the control of the cancer cell microenvironment to promote tumor angiogenesis. The nature and function of proteins found in the exosomal cargo, and the mechanism of their action in membrane transport and related signaling events are not clearly understood. In this study, we demonstrate, in human lung cancer A549 cells, that the exosome release mechanism is closely linked to the multifaceted receptor sortilin (also called neurotensin receptor 3). Sortilin is already known to be important for cancer cell function. Here, we report for the first time its role in the assembly of a tyrosine kinase complex and subsequent exosome release. This new complex (termed the TES complex) is found in exosomes and results in the linkage of the two tyrosine kinase receptors TrkB (also known as NTRK2) and EGFR with sortilin. Using in vitro models, we demonstrate that this sortilin-containing complex exhibits a control on endothelial cells and angiogenesis activation through exosome transfer.

Item Type: Article
Subjects: Q Science > QD Chemistry > QD0241 Organic chemistry > QD0415 Biochemistry
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Social and Applied Sciences > School of Human and Life Sciences
Depositing User: Cornelia Wilson
Date Deposited: 12 Jul 2016 15:38
Last Modified: 12 Jul 2016 15:38
URI: https://create.canterbury.ac.uk/id/eprint/14710

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Last edited: 29/06/2016 12:23:00