A new role under sortilin's belt in cancer.

Wilson, C. (2016) A new role under sortilin's belt in cancer. Communicative & Integrative Biology, 9 (1). ISSN 1942-0889.

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Abstract

The neurotensin receptor-3 also known as sortilin was the first member of the small family of vacuolar protein sorting 10 protein domain (Vps10p) discovered two decades ago in the human brain. The expression of sortilin is not confined to the nervous system but sortilin is ubiquitously expressed in many tissues. Sortilin has multiple roles in the cell as a receptor or a co-receptor, in protein transport of many interacting partners to the plasma membrane, to the endocytic pathway and to the lysosomes for protein degradation. Sortilin could be considered as the cells own shuttle system. In many human diseases including neurological diseases and cancer, sortilin expression has been shown to be deregulated. In addition, some studies have highlighted that the extracellular domain of sortilin is shedded into the culture media by an unknown mechanism. Sortilin can be released in exosomes and appears to control some mechanisms of exosome biogenesis. In lung cancer cells, sortilin can associate with two receptor tyrosine kinase receptors called the TES complex found in exosomes. Exosomes carrying the TES complex can convey a microenvironment control through the activation of ErbB signaling pathways and the release of angiogenic factors. Deregulation of sortilin function is now emerging to be implicated in four major human diseases- cardiovascular disease, Type 2 diabetes mellitus, Alzheimer’s disease and cancer.

Item Type: Article
Subjects: Q Science > QH Natural history > QH0301 Biology (General) > QH0426 Genetics
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Social and Applied Sciences > School of Human and Life Sciences
Depositing User: Cornelia Wilson
Date Deposited: 12 Jul 2016 15:57
Last Modified: 20 Sep 2016 16:52
URI: https://create.canterbury.ac.uk/id/eprint/14706

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Last edited: 29/06/2016 12:23:00