Venom: The sharp end of pain therapy

Trim, S. and Trim, C. (2013) Venom: The sharp end of pain therapy. British Journal of Pain, 7 (4). pp. 179-188. ISSN 2049-4637.

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Adequate pain control is still a significant challenge and largely unmet medical need in the 21st century. With many small molecules failing to reach required levels of potency and selectivity, drug discovery is
once again turning to nature to replenish pain therapeutic pipelines. Venomous animals are frequently stereotyped as inflictors of pain and distress and have historically been vilified by mankind. Yet, ironically, the very venoms that cause pain when directly injected by the host animal may actually turn out to contain the next generation of analgesics when injected by the clinician. The last 12 months have seen dramatic discoveries of analgesic tools within venoms. Spiders, snakes and even centipedes are yielding peptides with immense therapeutic potential. Significant advances are also taking place in delivery methods that can improve bioavailability and pharmacokinetics of these exciting natural resources. Turning proteinaceous venom into pharmaceutical liquid gold is the goal of venomics and the focus of this article.

Item Type: Article
Subjects: R Medicine > RB Pathology > RB0127 Manifestations of disease > RB0127.H355 Pain. Measurement
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculty of Social and Applied Sciences > School of Human and Life Sciences
Depositing User: Dr Carol Margaret Trim
Date Deposited: 15 Jul 2015 14:22
Last Modified: 15 Jul 2015 14:22

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Last edited: 29/06/2016 12:23:00